5-fluorouracil

Toxicity of 5-fluorouracil.

Fluorouracil (5-FU) is a relatively unique drug in oncology because administration in different doses and schedules results in dramatically different patterns of qualitative toxicity. In the 41 years 5-FU has been available to the clinical oncologist, a wide variety of doses and schedules of this agent have been used. Infusional schedules are associated with less myelosuppression but may have m...

Potently Immunosuppressive 5-Fluorouracil

[Angina related to 5-Fluorouracil].

Treatment with 5-fluorouracil is common in oncological patients. Side effects on bone marrow, skin, and mucous membranes have been reported. Cardiotoxicity, which is less predictable, can be life-threatening. Manifestations include angina, arrhythmias, infarction, heart failure and cardiogenic shock. The toxic mechanisms that might be involved have been much discussed but have not yet been clea...

Immune effects of 5-fluorouracil

Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting TH17 responses that compromise ...

[5-Fluorouracil-induced reticular hyperpigmentation].

superficial dermis with occasional melanophages (Figure 3). The patient continued to receive cycles of chemotherapy, with no observed increase in pigmentation, until completing the treatment after 11 infusions. Five months after the last cycle of chemotherapy and 8 months after the appearance of the hyperpigmentation, no pigmentation was seen on the palms of the hands, and the reticular pigment...